Light
Outdoors, plant polka dot plants in a location that receives some shade. Too much light can cause the plant's variegation to fade. Bright, indirect light from an east- or south-facing window is ideal indoors. 
 
Soil
Polka dot plants prefer soil rich in organic matter with good drainage. An all-purpose organic potting mix is typically suitable for these plants. Mix in some pumice or perlite to improve soil drainage.
 
Water
Keep the soil evenly moist. Water the plant when the top half-inch of soil has dried out. Cut back slightly on watering in the winter, then resume watering once you see new growth appear in the spring.
 
Temperature and Humidity
Keep your polka dot plant in a warm place with at least 50 percent humidity. They can be a great bathroom plant, if your bathroom has a window. Polka dot plants prefer temperatures over 60 degrees Fahrenheit, so they're only hardy outdoors in USDA growing zones 10 and 11. Move container plants outdoors in the spring after any danger of frost has passed, then bring them back indoors well before the first frost in fall if you plan to overwinter them.
 
Fertilizer
Feed container plants with an organic fertilizer designed for houseplants once a month during the warm growing season. If planting in-ground, mix organic compost into the soil each spring before planting.